Influence of Preformed Antibodies in Liver Transplantation

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Combined liver-kidney transplantation and the effect of preformed lymphocytotoxic antibodies.

Thirty-eight sequentially placed liver and kidney allografts were evaluated with respect to patient and graft survival, and the influence of preformed lymphocytotoxic antibodies was analysed. The results suggest that the survival rate of combined liver and kidney transplantation is similar to the survival rate of liver transplantation alone. Sequentially placed kidney allografts may be protecte...

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Combined liver-kidney transplantation: analysis of patients with preformed lymphocytotoxic antibodies.

W ITH THE INCREASING complexity of patients undergoing transplantation, the transplant services are called on to evaluate a variety of patients with concomitant metabolic derangements. Optimal function of an allograft and management of these patients in the posttransplant period may require consideration of multiorgan transplantation. The concept of multiorgan transplantation has become a reali...

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Effects of preformed antibodies induced by whole blood transfusion on small bowel transplantation.

Using inbred male LEW (RTl 1), BN CRTl"). ACI CRTI"). and PYG CRT! 0) rats weighing 200 to 300 g. orthotopic SBTx was periormed as described previously. I Donor-specific or third-party heparinized whole blood 0.0 mLl was given 7 days before transplantation. As a control. SBTx was periormed in untransfused recipients. Furthermore. the effect of blood transfusion on the incidence of graft versus ...

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Management of patients with preformed reactive antibodies who are awaiting cardiac transplantation.

Patients with elevated levels of preformed reactive antibodies to HLA antigens have higher rates of organ rejection than do patients without such antibodies. Consequently, before proceeding with transplantation, many medical centers do prospective cross-matching, that is, mix lymphocytes from the organ donor with sera from the prospective organ recipient, to determine whether a higher rejection...

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Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation.

Recent reports have suggested an association of antiDP antibodies with allograft rejection and graft loss, in both primary kidney transplant recipients and in re-grafts [1–3]. However, in most cases, it is difficult to separate the effects of anti-HLA-DP antibodies from other anti-HLA class I and class II antibodies. Among non-conserved haplotypes, HLA-DP allele mismatches occur despite matchin...

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ژورنال

عنوان ژورنال: Journal of Clinical Medicine

سال: 2020

ISSN: 2077-0383

DOI: 10.3390/jcm9030708